Article

Gene-based Hardy–Weinberg equilibrium test using genotype count data identifies novel cancer-related genes

2024-03-22

Abstract excerpt

<h4>Background</h4> An alternative approach to investigate associations between genetic variants and disease is to examine deviations from the Hardy–Weinberg equilibrium (HWE) in genotype frequencies within a case population, instead of case-control association analysis. The HWE analysis distinctively requires disease cases without the need for controls and demonstrates a notable ability in mapping recessive vari...

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Literature Corpus work: 5da78bce-6ceb-5b95-b4bb-a0cd6b63aea2
DOI: 10.1101/2024.03.20.24304529

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