Article

A Bayesian Nonparametric Approach to Discover Clinico-Genetic Associations across Cancer Types

2019-04-30

Abstract excerpt

<h4>Motivation</h4> Personalized medicine aims at combining genetic, clinical, and environmental data to improve medical diagnosis and disease treatment, tailored to each patient. This paper presents a Bayesian nonparametric (BNP) approach to identify genetic associations with clinical/environmental features in cancer. We propose an unsupervised approach to generate data-driven hypotheses and bring potentially no...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a0017b3-5774-5288-ad96-1425c4c86a7d
DOI: 10.1101/623215

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Bayesian Nonparametric Approach to Discover Clinico-Genetic Associations across Cancer TypesDOI 10.1101/623215Read

A Dirichlet-multinomial mixed model for detecting differential abundance of mutational signaturesSemantic proximity Read

Probabilistic modeling methods for cell-free DNA methylation based cancer classificationSemantic proximity Read

A Dirichlet-multinomial mixed model for determining differential abundance of mutational signaturesSemantic proximity Read

Predicting breast cancer risk using interacting genetic and demographic factors and machine learning.Semantic proximity Read

Multi-cancer risk stratification based on national health data: A retrospective modelling and validation studySemantic proximity Read

Comparing the value of mammographic features and genetic variants in breast cancer risk prediction.Semantic proximity Read

Gene-level heritability analysis explains the polygenic architecture of cancerSemantic proximity Read

Optimal Prescriptive Treatments for Ovarian Cancer with Genetic DataSemantic proximity Read

Bayesian Modeling of Cancer Outcomes Using Genetic Variables Assisted by Pathological Imaging Data.Semantic proximity Read

Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK BiobankSemantic proximity Read

A Bayesian Approach for Identifying Driver Mutations within Oncogenic Pathways through Mutual ExclusivitySemantic proximity Read

A fast and powerful tree-based association test for detecting complex joint effects in case-control studies.Semantic proximity Read