Article
Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Apr 2014
Arranz Amaia M, Perkins Katherine L, Irie Fumitoshi, Lewis David P, Hrabe Jan, Xiao Fanrong, Itano Naoki, Kimata Koji, Hrabetova Sabina, Yamaguchi Yu
Abstract excerpt
Hyaluronan (HA), a large anionic polysaccharide (glycosaminoglycan), is a major constituent of the extracellular matrix of the adult brain. To address its function, we examined the neurophysiology of knock-out mice deficient in hyaluronan synthase (Has) genes. Here we report that these Has mutant mice are prone to epileptic seizures, and that in Has3(-/-) mice, this phenotype is likely derived from a reduction in...
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