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Article

Hippocampal volume and cell density changes in a mouse model of human genetic epilepsy.

Neurology - 26 Mar 2013

Richards Kay L, Kurniawan Nyoman D, Yang Zhengyi, Kim Tae Hwan, Keller Marianne D, Low Jun, Ullmann Jeremy F P, Cole Stacey, Foong Samuel, Galloway Graham J, Reid Christopher A, Paxinos George, Reutens David C, Petrou Steven

Abstract excerpt

OBJECTIVE: The human γ-aminobutyric acid type A (GABAA)γ2R43Q (R43Q) mutation is associated with genetic epilepsy with febrile seizures. R43Q mice in the C57Bl/6J background do not display spontaneous seizures, but are significantly more susceptible to hyperthermic seizures, providing a model with enhanced seizure susceptibility without the confounding influence of ongoing epileptic activity. Because of GABA's...

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PMID: 23468543
DOI: 10.1212/WNL.0b013e31828970ec

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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