Article
Hippocampal Nabeta3 expression in patients with temporal lobe epilepsy.
Epilepsia - 1 Apr 2009
van Gassen Koen L I, de Wit Marina, van Kempen Marian, van der Hel W Saskia, van Rijen Peter C, Jackson Antony P, Lindhout Dick, de Graan Pierre N E
Abstract excerpt
Voltage-dependent sodium channels consist of a pore-forming alpha-subunit and regulatory beta-subunits. Alterations in these channels have been implicated in temporal lobe epilepsy (TLE) and several genetic epilepsy syndromes. Recently we identified Na(v)beta3 as a TLE-regulated gene. Here we performed a detailed analysis of the hippocampal expression of Na(v)beta3 in TLE patients with hippocampal sclerosis (HS)...
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