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Article

Klf15 Deficiency Is a Molecular Link Between Heart Failure and Aortic Aneurysm Formation

7 Apr 2010

Abstract excerpt

Current therapies for diseases of heart muscle (cardiomyopathy) and aorta (aortopathy) include inhibitors of the renin-angiotensin system, beta-adrenergic antagonists, and the statin class of cholesterol-lowering agents. These therapies have limited efficacy, as adverse cardiovascular events continue to occur with some frequency in patients taking these drugs. Although cardiomyopathy and aortopathy can coexist in...

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PMID: 20375365
DOI: 10.1126/scitranslmed.3000502

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