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Article

WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.

The Journal of biological chemistry - 29 May 2015

Maeda Azusa, Ono Mitsuaki, Holmbeck Kenn, Li Li, Kilts Tina M, Kram Vardit, Noonan Megan L, Yoshioka Yuya, McNerny Erin M B, Tantillo Margaret A, Kohn David H, Lyons Karen M, Robey Pamela G, Young Marian F

Abstract excerpt

WISP1/CCN4 (hereafter referred to as WISP1), a member of the CCN family, is found in mineralized tissues and is produced by osteoblasts and their precursors. In this study, Wisp1-deficient (Wisp1(-/-)) mice were generated. Using dual-energy x-ray absorptiometry, we showed that by 3 months, the total bone mineral density of Wisp1(-/-) mice was significantly lower than that of WT mice. Further investigation by...

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Source

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Identifiers

PMID: 25864198
DOI: 10.1074/jbc.M114.628818
PMCID: PMC4447973

Genes

CCN4
LRP6
SOST
WNT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.PMID 25864198Read ↗

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