Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KNDC1 knockdown protects human umbilical vein endothelial cells from senescence.

Molecular medicine reports - 1 Jul 2014

Zhang Chunyan, Zhen Yong-Zhan, Lin Ya-Jun, Liu Jiang, Wei Jie, Xu Rong, Hu Gang

Abstract excerpt

KNDC1 (kinase noncatalytic C-lobe domain containing 1), a brain-specific Ras guanine nucleotide exchange factor, controls the negative regulation of neuronal dendrite growth. However, the effect of KNDC1 on cellular senescence remains to be elucidated. The present study investigated the impact of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Cellular Senescence
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Guanine Nucleotide Exchange Factors

Share to Human Umbilical Vein Endothelial Cells

Share to Neovascularization, Physiologic

Share to Nitric Oxide Synthase Type III

Source

Open in PubMed Open full text

Identifiers

PMID: 24788352
DOI: 10.3892/mmr.2014.2201
PMCID: PMC4068720

Genes

KNDC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24788352-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KNDC1 knockdown protects human umbilical vein endothelial cells from senescence.PMID 24788352Read ↗

Vascular cellular senescence in human atherosclerosis: The critical modulating roles of CDKN2A and CDK4/6 signaling pathwaysSemantic proximity Read ↗

Alteration of E2F2 Expression in Governing Endothelial Cell SenescenceSemantic proximity Read ↗

Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway.Semantic proximity Read ↗

c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype.Semantic proximity Read ↗

Loss of NF1 Expression in Human Endothelial Cells Promotes Autonomous Proliferation and Altered Vascular MorphogenesisSemantic proximity Read ↗

Nek6 overexpression antagonizes p53-induced senescence in human cancer cellsSemantic proximity Read ↗

Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repairSemantic proximity Read ↗

Contribution of p16 INK4a and p21 CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53Semantic proximity Read ↗

High levels of oncomi R ‐21 contribute to the senescence‐induced growth arrest in normal human cells and its knock‐down increases the replicative lifespanSemantic proximity Read ↗

Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunctionSemantic proximity Read ↗

REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stressSemantic proximity Read ↗

Endothelial<i>Cdkn1a</i>(<i>p21</i>) Overexpression and Accelerated Senescence in a Mouse Model of Fuchs Endothelial Corneal DystrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.