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Article

Global microRNA depletion suppresses tumor angiogenesis.

Genes & development - 15 May 2014

Chen Sidi, Xue Yuan, Wu Xuebing, Le Cong, Bhutkar Arjun, Bell Eric L, Zhang Feng, Langer Robert, Sharp Phillip A

Abstract excerpt

MicroRNAs delicately regulate the balance of angiogenesis. Here we show that depletion of all microRNAs suppresses tumor angiogenesis. We generated microRNA-deficient tumors by knocking out Dicer1. These tumors are highly hypoxic but poorly vascularized, suggestive of deficient angiogenesis signaling. Expression profiling revealed that angiogenesis genes were significantly down-regulated as a result of the...

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Identifiers

PMID: 24788094
DOI: 10.1101/gad.239681.114
PMCID: PMC4035535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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