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Article

Differential effect of vitamin D on NOD2- and TLR-induced cytokines in Crohn's disease.

Mucosal immunology - 1 Nov 2014

Dionne S, Calderon M R, White J H, Memari B, Elimrani I, Adelson B, Piccirillo C, Seidman E G

Abstract excerpt

Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene expression and its downstream function. We hypothesized that the hormonal form of vD (1,25D) could...

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Source

Identifiers

PMID: 24781050
DOI: 10.1038/mi.2014.30

Genes

NOD2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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