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Article

Cell cycle-specific cleavage of Scc2 regulates its cohesin deposition activity.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 2014

Woodman Julie, Fara Tyler, Dzieciatkowska Monika, Trejo Michael, Luong Nancy, Hansen Kirk C, Megee Paul C

Abstract excerpt

Sister chromatid cohesion (SCC), efficient DNA repair, and the regulation of some metazoan genes require the association of cohesins with chromosomes. Cohesins are deposited by a conserved heterodimeric loading complex composed of the Scc2 and Scc4 proteins in Saccharomyces cerevisiae, but how the Scc2/Scc4 deposition complex regulates the spatiotemporal association of cohesin with chromosomes is not understood....

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Identifiers

PMID: 24778232
DOI: 10.1073/pnas.1321722111
PMCID: PMC4024903

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