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Increased androgen receptor gene copy number is associated with <i>TMPRSS2‐ERG</i> rearrangement in prostatic small cell carcinoma

29 Apr 2014

Abstract excerpt

Small cell carcinoma of the prostate (PSCC) is a highly aggressive malignancy that often develops in patients previously treated with hormonal therapy for metastatic prostatic acinar adenocarcinoma. The TMPRSS2-ERG gene rearrangement is highly specific for prostate cancer and shared by PSCC; however, the role of androgen receptor (AR) gene alterations and interaction with TMPRSS2-ERG rearrangement are...

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PMID: 24777847
DOI: 10.1002/mc.22162

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