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Article

Frequency of the <i>TMPRSS2:ERG</i> gene fusion is increased in moderate to poorly differentiated prostate cancers

26 Jan 2007

Abstract excerpt

BACKGROUND: Recent reports indicate that prostate cancers (CaP) frequently over-express the potential oncogenes, ERG or ETV1. Many cases have chromosomal rearrangements leading to the fusion of the 5' end of the androgen-regulated serine protease TMPRSS2 (21q22.2) to the 3' end of either ERG (21q22.3) or ETV1 (7p21.3). The consequence of these rearrangements is aberrant androgen receptor-driven expression of the...

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Identifiers

PMID: 17259299
DOI: 10.1136/jcp.2006.043810

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Research trail→

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Frequency of the <i>TMPRSS2:ERG</i> gene fusion is increased in moderate to poorly differentiated prostate cancersPMID 17259299Read ↗

<i>TMPRSS2</i> : <i>ERG</i> Fusion Identifies a Subgroup of Prostate Cancers with a Favorable PrognosisSemantic proximity Read ↗

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Molecular Characterization and Clinical Impact of<i>TMPRSS2-ERG</i>Rearrangement on Prostate Cancer: Comparison between FISH and RT-PCRSemantic proximity Read ↗

TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN LesionsSemantic proximity Read ↗

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Clinical Applications of Novel ERG Immunohistochemistry in Prostate Cancer Diagnosis and ManagementSemantic proximity Read ↗

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