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Article

<i>TMPRSS2-ERG</i> Gene Fusion Is Not Associated with Outcome in Patients Treated by Prostatectomy

3 Feb 2009

Abstract excerpt

A significant number of prostate cancers have been shown to have recurrent chromosomal rearrangements resulting in the fusion of the androgen-regulated TMPRSS2 promoter to a member of the ETS transcription factor family, most commonly ERG. This results in ERG overexpression, which may have a direct causal role in prostate tumorigenesis or progression. However, the clinical significance of the rearrangement is...

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PMID: 19190343
DOI: 10.1158/0008-5472.can-08-2467

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Related research

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<i>TMPRSS2-ERG</i> Gene Fusion Is Not Associated with Outcome in Patients Treated by ProstatectomyPMID 19190343Read ↗

Increased gene copy number of ERG on chromosome 21 but not TMPRSS2-ERG fusion predicts outcome in prostatic adenocarcinomas.Semantic proximity Read ↗

<i>TMPRSS2</i> : <i>ERG</i> Fusion Identifies a Subgroup of Prostate Cancers with a Favorable PrognosisSemantic proximity Read ↗

Molecular Characterization and Clinical Impact of<i>TMPRSS2-ERG</i>Rearrangement on Prostate Cancer: Comparison between FISH and RT-PCRSemantic proximity Read ↗

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN LesionsSemantic proximity Read ↗

<i>TMPRSS2:ERG</i> Fusion by Translocation or Interstitial Deletion Is Highly Relevant in Androgen-Dependent Prostate Cancer, But Is Bypassed in Late-Stage Androgen Receptor–Negative Prostate CancerSemantic proximity Read ↗

Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.Semantic proximity Read ↗

Recurrent Fusion of <i>TMPRSS2</i> and ETS Transcription Factor Genes in Prostate CancerSemantic proximity Read ↗

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.Semantic proximity Read ↗

Overexpression of Prostate-Specific <i>TMPRSS2(exon 0)-ERG</i> Fusion Transcripts Corresponds with Favorable Prognosis of Prostate CancerSemantic proximity Read ↗

<i>TMPRSS2:ETV4</i> Gene Fusions Define a Third Molecular Subtype of Prostate CancerSemantic proximity Read ↗

Frequency of the <i>TMPRSS2:ERG</i> gene fusion is increased in moderate to poorly differentiated prostate cancersSemantic proximity Read ↗

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