Recent advances in the genetics of dementia with lewy bodies.

doi:10.1007/s11910-008-0030-1

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Article

Recent advances in the genetics of dementia with lewy bodies.

Current neurology and neuroscience reports - 1 May 2008

Bonifati Vincenzo

Abstract excerpt

In the past few years, mutations have been identified in the genes encoding alpha-synuclein, leucine-rich repeat kinase 2, and glucocerebrosidase in some patients with dementia with Lewy bodies (DLB). Furthermore, a novel locus for familial DLB has been mapped to chromosome 2q35-q36. Collectively, these discoveries highlight a substantial overlap between the known genetic determinants of Parkinson's disease and...

Topics

Glucosylceramidase
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Lewy Body Disease
Mutation
Protein Serine-Threonine Kinases
alpha-Synuclein

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Open in PubMed

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PMID: 18541113
DOI: 10.1007/s11910-008-0030-1

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