Article
Alternative variants of human HYDIN are novel cancer-associated antigens recognized by adaptive immunity.
Cancer immunology research - 1 Sept 2013
Laske Karoline, Shebzukhov Yuriy V, Grosse-Hovest Ludger, Kuprash Dmitry V, Khlgatian Svetlana V, Koroleva Ekaterina P, Sazykin Alexey Y, Penkov Dmitry N, Belousov Pavel V, Stevanovic Stefan, Vass Verona, Walter Steffen, Eisel David, Schmid-Horch Barbara D, Nedospasov Sergei A, Rammensee Hans-Georg, Gouttefangeas Cécile
Abstract excerpt
A mutation in the hydin gene has been recently described as one possible mechanism leading to lethal congenital hydrocephalus in mice, and a similar defect is proposed to be involved in an autosomal recessive form of hydrocephalus in human. Here, we report for the first time on the cancer association and immunogenicity of two HYDIN variants in humans. One is a previously described sequence derived from the...
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