Article
Identification of a novel human cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2004
Monji Mikio, Nakatsura Tetsuya, Senju Satoru, Yoshitake Yoshihiro, Sawatsubashi Motohiro, Shinohara Masanori, Kageshita Toshiro, Ono Tomomichi, Inokuchi Akira, Nishimura Yasuharu
Abstract excerpt
PURPOSE: We used serologic screening of a cDNA expression library of human testis to identify novel cancer/testis antigens that elicit both humoral and cellular immune responses in cancer patients. EXPERIMENTAL DESIGN AND RESULTS: We identified a novel gene designated KM-HN-1 the expression of which is testis-specific among normal tissues; it contains coiled coil domains and a leucine zipper motif and encodes a...
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