Article
CD4(+) T cells from healthy subjects and colon cancer patients recognize a carcinoembryonic antigen-specific immunodominant epitope.
Cancer research - 1 Dec 2003
Campi Gabriele, Crosti Mariacristina, Consogno Giuseppe, Facchinetti Valeria, Conti-Fine Bianca M, Longhi Renato, Casorati Giulia, Dellabona Paolo, Protti Maria Pia
Abstract excerpt
The carcinoembryonic antigen (CEA) is an attractive target for immunotherapeutic purposes because of its expression profile, its role in tumor progression, and its immunogenicity. However, CEA belongs to the CD66 immunoglobulin super-gene family that comprises highly homologous molecules expresse...
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