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Article

Understanding the IDH1 missense SNPs on expression of genes involved in Glioblastoma multiforme.

Computational biology and chemistry - 1 Oct 2025

Kakde Ganesh Sanjay, Dakal Tikam Chand, Maurya Pawan Kumar

Abstract excerpt

The IDH1 gene encodes isocitrate dehydrogenase 1 enzyme (IDH1), crucial in the citric acid cycle that converts isocitrate to alpha-ketoglutarate. Mutations in IDH1 at R132 lead to the production of the oncometabolite 2-hydroxyglutarate, which impacts cellular metabolism, differentiation, and epigenetic regulation, and is associated with GBM. This study utilized in silico methods (SIFT, PROVEAN, PolyPhen2, Predict...

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Identifiers

PMID: 40306098
DOI: 10.1016/j.compbiolchem.2025.108487

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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