Article
MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Dec 2007
Müller Sebastian, Keil Thomas, Grüber Christoph, Zitnik Simona Eva, Lau Susanne, Wahn Ulrich, Witt Heiko, Nickel Renate
Abstract excerpt
Mannose-binding lectin (MBL) is considered an important component of innate immunity. Four functional MBL2 alterations in codons 52, 54, 57 and in the promoter at position c.1-290 are correlated with significantly lowered MBL serum levels. These variants have been associated with susceptibility to a variety of infectious agents as well as with various immunologic disorders including asthma. To reassess these...
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