Article
Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome.
Neurobiology of disease - 1 Aug 2014
De Felice Claudio, Della Ragione Floriana, Signorini Cinzia, Leoncini Silvia, Pecorelli Alessandra, Ciccoli Lucia, Scalabrì Francesco, Marracino Federico, Madonna Michele, Belmonte Giuseppe, Ricceri Laura, De Filippis Bianca, Laviola Giovanni, Valacchi Giuseppe, Durand Thierry, Galano Jean-Marie, Oger Camille, Guy Alexandre, Bultel-Poncé Valérie, Guy Jacky, Filosa Stefania, Hayek Joussef, D'Esposito Maurizio
Abstract excerpt
Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caused in the overwhelming majority of the cases by loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2). High circulating levels of oxidative stress (OS) markers in pat...
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