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Article

Increased levels of 4HNE-protein plasma adducts in Rett syndrome.

Clinical biochemistry - 1 Apr 2011

Pecorelli Alessandra, Ciccoli Lucia, Signorini Cinzia, Leoncini Silvia, Giardini Anna, D'Esposito Maurizio, Filosa Stefania, Hayek Joussef, De Felice Claudio, Valacchi Giuseppe

Abstract excerpt

OBJECTIVE: Rett syndrome (RTT) is a neurological disorder and a leading cause of mental retardation in females. It is caused by mutations in methyl-CpG-binding protein 2 (MeCP2) gene and more rarely in cyclin-dependent kinase-like 5 (CDKL5) and forkhead box protein G1 (FOXG1) genes. Increased oxidative stress (OS) has been documented in MeCP2-RTT patients. Here, we evaluated the levels of 4-hydroxynonenal plasma...

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Source

Identifiers

PMID: 21276437
DOI: 10.1016/j.clinbiochem.2011.01.007

Genes

CDKL5
FOXG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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