Article
Systemic oxidative stress in classic Rett syndrome.
Free radical biology & medicine - 15 Aug 2009
De Felice Claudio, Ciccoli Lucia, Leoncini Silvia, Signorini Cinzia, Rossi Marcello, Vannuccini Laura, Guazzi Gianni, Latini Giuseppe, Comporti Mario, Valacchi Giuseppe, Hayek Joussef
Abstract excerpt
Rett syndrome (RS), a progressive severe neurodevelopmental disorder mainly caused by de novo mutations in the X-chromosomal MeCP2 gene encoding the transcriptional regulator methyl-CpG-binding protein 2, is a leading cause of mental retardation with autistic features in females. However, its pathogenesis remains incompletely understood, and no effective therapy is available to date. We hypothesized that a...
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