Article
F₄-neuroprostanes mediate neurological severity in Rett syndrome.
Clinica chimica acta; international journal of clinical chemistry - 15 Jul 2011
Signorini Cinzia, De Felice Claudio, Leoncini Silvia, Giardini Anna, D'Esposito Maurizio, Filosa Stefania, Della Ragione Floriana, Rossi Marcello, Pecorelli Alessandra, Valacchi Giuseppe, Ciccoli Lucia, Hayek Joussef
Abstract excerpt
BACKGROUND: Rett syndrome (RTT) is a pervasive development disorder, mainly caused by mutations in the methyl-CpG binding protein 2 (MeCP2) gene. No reliable biochemical markers of the disease are available. Here we assess F₄-neuroprostanes (F₄-NeuroPs), lipid peroxidation products of the docosahexaenoic acid, as a novel disease marker in RTT and correlate it with clinical presentation, MeCP2 mutation type, and...
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