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Article

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.

Biochemical and biophysical research communications - 21 Feb 2014

Rowe Isaline, Chiaravalli Marco, Piontek Klaus B, Germino Gregory G, Boletta Alessandra

Abstract excerpt

The PKD1 gene is essential for a number of biological functions, and its loss-of-function causes autosomal dominant polycystic kidney disease (ADPKD). The gene is developmentally regulated and believed to play an essential role in renal development. Previous studies have shown that manipulating murine renal organ cultures with dominant-negative forms of the Pkd1 gene impaired ureteric bud (UB) branching. In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24472557
DOI: 10.1016/j.bbrc.2014.01.068
PMCID: PMC3945815

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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