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Article

JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.

PLoS pathogens - 1 Apr 2014

Sundqvist Emilie, Buck Dorothea, Warnke Clemens, Albrecht Eva, Gieger Christian, Khademi Mohsen, Lima Bomfim Izaura, Fogdell-Hahn Anna, Link Jenny, Alfredsson Lars, Søndergaard Helle Bach, Hillert Jan, Oturai Annette B, Hemmer Bernhard, Hemme Bernhard, Kockum Ingrid, Olsson Tomas

Abstract excerpt

JC polyomavirus (JCV) carriers with a compromised immune system, such as in HIV, or subjects on immune-modulating therapies, such as anti VLA-4 therapy may develop progressive multifocal leukoencephalopathy (PML) which is a lytic infection of oligodendrocytes in the brain. Serum antibodies to JCV mark infection occur only in 50-60% of infected individuals, and high JCV-antibody titers seem to increase the risk of...

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Identifiers

PMID: 24763718
DOI: 10.1371/journal.ppat.1004084
PMCID: PMC3999271

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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