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Article

Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod.

Journal of neuroinflammation - 9 Jul 2020

Watanabe Mitsuru, Nakamura Yuri, Isobe Noriko, Tanaka Masami, Sakoda Ayako, Hayashi Fumie, Kawano Yuji, Yamasaki Ryo, Matsushita Takuya, Kira Jun-Ichi

Abstract excerpt

BACKGROUND: Progressive multifocal leukoencephalopathy (PML) caused by JC virus (JCV) is a rare but serious complication of some disease-modifying drugs used to treat multiple sclerosis (MS). Japanese MS patients treated with fingolimod were reported to be 10 times more likely to develop PML than equivalent patients in other countries. The strongest susceptibility human leukocyte antigen (HLA) class II alleles...

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Identifiers

PMID: 32646493
DOI: 10.1186/s12974-020-01865-7
PMCID: PMC7350631

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