Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2014

Hartmann Natalie, Giese Nathalia A, Giese Thomas, Poschke Isabel, Offringa Rienk, Werner Jens, Ryschich Eduard

Abstract excerpt

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive collagen-rich stroma. T cells that infiltrate pancreatic cancers frequently become trapped in the stroma and do not contact tumor cells. Here, we aimed to analyze how chemokines and extracellular matrix (ECM) collagen interact in mediating T-cell infiltration in PDAC. EXPERIMENTAL DESIGN: T-cell distribution and ECM structure within...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal
Share to Cell Communication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokines

Share to Chemotaxis, Leukocyte

Share to Extracellular Matrix

Share to Integrin beta1

Share to Lymphocytes, Tumor-Infiltrating

Share to Stromal Cells

Source

Identifiers

PMID: 24763614
DOI: 10.1158/1078-0432.CCR-13-2972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.PMID 24763614Read ↗

Collagen type I promotes pancreatic tumor growth and limits immune cell infiltrationSemantic proximity Read ↗

Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.Semantic proximity Read ↗

Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer.Semantic proximity Read ↗

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cellsSemantic proximity Read ↗

Phenotypic Heterogeneity and Plasticity of Cancer Cell Migration in a Pancreatic Tumor Three-Dimensional Culture ModelSemantic proximity Read ↗

Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM CompositionSemantic proximity Read ↗

Cancer Associated Fibroblast (CAF) regulation of PDAC parenchymal (CPC) and CSC phenotypes is modulated by ECM composition.Semantic proximity Read ↗

DDR1-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS DRIVE PANCREATIC CANCER METASTASISSemantic proximity Read ↗

Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer modelSemantic proximity Read ↗

Drug resistant pancreatic cancer cells exhibit altered biophysical interactions with stromal fibroblasts in imaging studies of 3D co-culture modelsSemantic proximity Read ↗

Altered Mechanobiology of PDAC Cells with Acquired Chemoresistance to Gemcitabine and PaclitaxelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.