Article
Basal core promoter mutation is associated with progression to cirrhosis rather than hepatocellular carcinoma in chronic hepatitis B virus infection.
British journal of cancer - 4 Dec 2012
Chu C-M, Lin C-C, Chen Y-C, Jeng W-J, Lin S-M, Liaw Y-F
Abstract excerpt
BACKGROUND: As most cases of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) have concurrent cirrhosis, viral factors identified to be associated with HCC might be related to cirrhosis rather than HCC. METHODS: Hepatitis B virus DNA levels, genotypes and precore/basal core promoter...
Topics
- Adult
- Aged
- Carcinoma, Hepatocellular
- Case-Control Studies
- DNA, Viral
- Disease Progression
- Female
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Liver Cirrhosis
- Liver Neoplasms
- Logistic Models
- Male
- Middle Aged
- Mutation
- Promoter Regions, Genetic