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Article

Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome.

PloS one - 7 Jun 2010

Gui Junhong, Wang Tao, Jones Richard P O, Trump Dorothy, Zimmer Thomas, Lei Ming

Abstract excerpt

BACKGROUND: To identify molecular mechanisms underlying SCN5A-related sick sinus syndrome (SSS), a rare type of SSS, in parallel experiments we elucidated the electrophysiological properties and the cell surface localization of thirteen human Na(v)1.5 (hNa(v)1.5) mutant channels previously linked to this disease. METHODOLOGY/PRINCIPAL FINDINGS: Mutant hNa(v)1.5 channels expressed by HEK293 cells and Xenopus...

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Source

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Identifiers

PMID: 20539757
DOI: 10.1371/journal.pone.0010985
PMCID: PMC2881866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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