Article
Methylation in eucaryotes influences the repair of G/T and A/C DNA basepair mismatches.
Cell biophysics - 1 Jan 2000
Hare J T, Taylor J H
Abstract excerpt
Although methylation of DNA at some sites regulates gene expression, 5mC at many sites does not appear to have any effect. We present evidence that hemimethylation at many different sites can act as a discrimination signal in mismatch repair. Deamination of 5mC in a symmetrically methylated doublet CpG yields the mismatched base pair T/G in a hemi-methylated doublet pair. Because both bases in the mismatched pair...
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