Article
Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.
The Journal of allergy and clinical immunology - 1 Mar 2016
Yee Christina S, Massaad Michel J, Bainter Wayne, Ohsumi Toshiro K, Föger Niko, Chan Andrew C, Akarsu Nurten A, Aytekin Caner, Ayvaz Deniz Çagdas, Tezcan Ilhan, Sanal Özden, Geha Raif S, Chou Janet
Abstract excerpt
BACKGROUND: Coronin-1A (CORO1A) is a regulator of actin dynamics important for T-cell homeostasis. CORO1A deficiency causes T(-)B(+) natural killer-positive severe combined immunodeficiency or T-cell lymphopenia with severe viral infections. However, because all known human mutations in CORO1A abrogate protein expression, the role of the protein's functional domains in host immunity is unknown. OBJECTIVE: We...
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