Article
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
Immunity - 1 Jan 2008
Haraldsson M Katarina, Louis-Dit-Sully Christine A, Lawson Brian R, Sternik Gabriel, Santiago-Raber Marie-Laure, Gascoigne Nicholas R J, Theofilopoulos Argyrios N, Kono Dwight H
Abstract excerpt
Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated with developmental and functional alterations in T cells including reduced migration, survival, activation, and Ca2+ flux. T-dependent humoral responses were impaired, but no intrinsic B cell defects were detected. By transfer of T cells, it was shown that...
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