Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human.

Human molecular genetics - 1 Sept 2014

Zhou Bo, Wei Fan-Yan, Kanai Narumi, Fujimura Atsushi, Kaitsuka Taku, Tomizawa Kazuhito

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) in CDKAL1 have been associated with the development of type 2 diabetes (T2D). CDKAL1 catalyzes 2-methylthio modification of adenosine at position 37 of tRNA(Lys)(UUU). A deficit of this modification causes aberrant protein synthesis, and is associated with i...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Cyclin-Dependent Kinase 5
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Insulin Secretion

Share to Open Reading Frames

Share to RNA, Untranslated

Share to tRNA Methyltransferases

Source

Identifiers

PMID: 24760768
DOI: 10.1093/hmg/ddu184

Genes

CDKAL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24760768-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human.PMID 24760768Read ↗

Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes.Semantic proximity Read ↗

Development of type 2 diabetes caused by a deficiency of a tRNA(lys) modification.Semantic proximity Read ↗

Quantitative PCR measurement of tRNA 2-methylthio modification for assessing type 2 diabetes risk.Semantic proximity Read ↗

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1.Semantic proximity Read ↗

The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel.Semantic proximity Read ↗

Role of long non-coding RNA in T1DM.Semantic proximity Read ↗

Post-transcriptional control of candidate risk genes for type 1 diabetes by rare genetic variants.Semantic proximity Read ↗

CDKAL1 gene rs7756992 A/G polymorphism and type 2 diabetes mellitus: a meta-analysis of 62,567 subjects.Semantic proximity Read ↗

Association of the CDKAL1 polymorphism rs10946398 with type 2 diabetes mellitus in adults: A meta-analysis.Semantic proximity Read ↗

CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Gene Polymorphisms and Gestational Diabetes Mellitus Risk: A Trial Sequential Meta-Analysis of 13,306 Subjects.Semantic proximity Read ↗

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.Semantic proximity Read ↗

An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.