Article
Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects.
PloS one - 1 Jan 2014
Ayala de la Peña Francisco, Kanasaki Keizo, Kanasaki Megumi, Vong Sylvia, Rovira Carlota, Kalluri Raghu
Abstract excerpt
K-ras is essential for embryogenesis and its mutations are involved in human developmental syndromes and cancer. To determine the consequences of K-ras activation in urothelium, we used uroplakin-II (UPK II) promoter driven Cre recombinase mice and generated mice with mutated KrasG12D allele in the urothelium (UPK II-Cre;LSL-K-rasG12D). The UPK II-Cre;LSL-K-rasG12D mice died neonatally due to lung morphogenesis...
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