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Article

Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases.

The Journal of cell biology - 20 Dec 2004

Kong Xiang-Tian, Deng Fang-Ming, Hu Ping, Liang Feng-Xia, Zhou Ge, Auerbach Anna B, Genieser Nancy, Nelson Peter K, Robbins Edith S, Shapiro Ellen, Kachar Bechara, Sun Tung-Tien

Abstract excerpt

The apical surface of mouse urothelium is covered by two-dimensional crystals (plaques) of uroplakin (UP) particles. To study uroplakin function, we ablated the mouse UPII gene. A comparison of the phenotypes of UPII- and UPIII-deficient mice yielded new insights into the mechanism of plaque formation and some fundamental features of urothelial differentiation. Although UPIII knockout yielded small plaques, UPII...

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Identifiers

PMID: 15611339
DOI: 10.1083/jcb.200406025
PMCID: PMC2172608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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