Rationally designed perturbation factor drives evolution in Saccharomyces cerevisiae for industrial application.

doi:10.1007/s10295-018-2057-x

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Article

Rationally designed perturbation factor drives evolution in Saccharomyces cerevisiae for industrial application.

Journal of industrial microbiology & biotechnology - 1 Oct 2018

Xu Xin, Liu Chunfeng, Niu Chengtuo, Wang Jinjing, Zheng Feiyun, Li Yongxian, Li Qi

Abstract excerpt

Saccharomyces cerevisiae strains with favorable characteristics are preferred for application in industries. However, the current ability to reprogram a yeast cell on the genome scale is limited due to the complexity of yeast ploids. In this study, a method named genome replication engineering-assisted continuous evolution (GREACE) was proved efficient in engineering S. cerevisiae with different ploids. Through...

Topics

Acetaldehyde
Acetic Acid
Beer
DNA Replication
DNA-Directed DNA Polymerase
Directed Molecular Evolution
Fermentation
Food Microbiology
Genetic Engineering
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Fungal

Industrial Microbiology

Mutation

Phenotype

Plasmids

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

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PMID: 30076552
DOI: 10.1007/s10295-018-2057-x

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