Article
Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue.
Hepatology (Baltimore, Md.) - 1 Nov 2014
Piconese Silvia, Timperi Eleonora, Pacella Ilenia, Schinzari Valeria, Tripodo Claudio, Rossi Massimo, Guglielmo Nicola, Mennini Gianluca, Grazi Gian Luca, Di Filippo Simona, Brozzetti Stefania, Fazzi Katia, Antonelli Guido, Lozzi Maria Antonietta, Sanchez Massimo, Barnaba Vincenzo
Abstract excerpt
UNLABELLED: Regulatory T cells (Tregs) can be considered as a mixed population of distinct subsets, endowed with a diverse extent and quality of adaptation to microenvironmental signals. Here, we uncovered an opposite distribution of Treg expansion, phenotype, and plasticity in different microenvironments in the same organ (liver) derived from patients with chronic hepatitis C: On the one side, cirrhotic and...
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