Article
Upregulation of OX40 ligand on monocytes contributes to early virological control in patients with chronic hepatitis C.
European journal of immunology - 1 Jul 2013
Zhang Ji-Yuan, Wu Xiao-Li, Yang Bin, Wang Yu, Feng Guo-Hua, Jiang Tian-Jun, Zeng Qing-Lei, Xu Xiang-Sheng, Li Yuan-Yuan, Jin Lei, Lv Sa, Zhang Zheng, Fu Junliang, Wang Fu-Sheng
Abstract excerpt
Dysfunctional hepatitis C virus (HCV) specific CD4(+) T cells are known to contribute to inadequate adaptive immunity in chronic hepatitis C (CHC), although the underlying mechanisms remain largely undefined. In this study, OX40 ligand (OX40L) expression was investigated in 41 treatment-naïve CHC patients, 20 sustained virological responders and 36 healthy subjects. We observed that OX40L expression was...
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