Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with epithelial ovarian cancer.

doi:10.1016/j.humimm.2014.04.002

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Article

Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with epithelial ovarian cancer.

Human immunology - 1 Jun 2014

Giebel Sebastian, Boratyn-Nowicka Agnieszka, Karabon Lidia, Jedynak Anna, Pamula-Pilat Jolanta, Tecza Karolina, Kula Dorota, Kowal Monika, Frydecka Irena, Grzybowska Ewa

Abstract excerpt

Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic. In this study we analyzed associations of KIR and KIR ligand genes with the incidence and clinical course of epithelial ovarian cancer. DNA of 142 patients...

Topics

Adenocarcinoma, Mucinous
Adult
Aged
Aged, 80 and over
Alleles
Carcinoma, Endometrioid
Carcinoma, Ovarian Epithelial
Case-Control Studies
Cystadenocarcinoma, Serous
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression

Gene Frequency

Genetic Predisposition to Disease

HLA-C Antigens

Humans

Killer Cells, Natural

Ligands

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 24755350
DOI: 10.1016/j.humimm.2014.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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