Article
KIRs gene content diversity in Iranians with urothelial bladder cancer.
Molecular biology reports - 1 Oct 2018
Jamali Elham, Barani Shaghik, Yousefinejad Fahimeh, Ariafar Ali, Talei Ghoalm Reza, Ghaderi Abbas
Abstract excerpt
Natural killer cells (NK) are the first arm of the innate immune system in defense against tumor and infection. 16 distinct Killer-cell immunoglobulin-like receptors (KIRs) are involved in orchestrating NK cell function. The KIR family contains 14 genes and 2 pseudogenes. Six of these receptors are activating (aKIR) and the remaining receptors are inhibitory KIRs (iKIR), that interact with MHC-I molecules;...
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