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Article

The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain.

PloS one - 1 Jan 2015

Peng Hu, Zhuang Yugang, Chen Yuanzhuo, Rizzo Alicia N, Chen Weiguo

Abstract excerpt

In addition to superoxide (O2.-) generation from nitric oxide synthase (NOS) oxygenase domain, a new O2.- generation site has been identified in the reductase domain of inducible NOS (iNOS) and neuronal NOS (nNOS). Cysteine S-glutathionylation in eNOS reductase domain also induces O2.- generation from eNOS reductase domain. However, the characteristics and regulatory mechanism of the O2.- generation from NOS...

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PMID: 26465144
DOI: 10.1371/journal.pone.0140365
PMCID: PMC4605588

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