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Article

O-GlcNAcylation Mediates Glucose-Induced Alterations in Endothelial Cell Phenotype in Human Diabetes Mellitus.

Journal of the American Heart Association - 16 Jun 2020

Masaki Nobuyuki, Feng Bihua, Bretón-Romero Rosa, Inagaki Elica, Weisbrod Robert M, Fetterman Jessica L, Hamburg Naomi M

Abstract excerpt

Background Posttranslational protein modification with O-linked N-acetylglucosamine (O-GlcNAc) is linked to high glucose levels in type 2 diabetes mellitus (T2DM) and may alter cellular function. We sought to elucidate the involvement of O-GlcNAc modification in endothelial dysfunction in patients with T2DM. Methods and Results Freshly isolated endothelial cells obtained by J-wire biopsy from a forearm vein of...

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Identifiers

PMID: 32508185
DOI: 10.1161/JAHA.119.014046
PMCID: PMC7429031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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