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Article

Diagnostic and prophylactic potential of a stabilized foot-and-mouth disease serotype Asia1 virus like particles designed through a structure guided approach.

International journal of biological macromolecules - 1 Oct 2024

Aparna Madhavan, Saravanan Paramasivam, Dhanesh V V, Selvaraj Deepak Praveen Raj, Shreya Gopinath, Adwitiya Das, Madhusudan Hosamani, Sreenivasa B P, Tamilselvan R P, Sanyal Aniket, Goyal Samta, Thiyagarajan Saravanamuthu, Chaudhuri Pallab

Abstract excerpt

Intact capsids of foot-and-mouth disease virus (FMDV) play a vital role in eliciting a protective immune response. Any change in the physico-chemical environment of the capsids results in dissociation and poor immunogenicity. Structural bioinfomatics studies have been carried out to predict the amino acids at the interpentameric region that resulted in the identification of mutant virus-like particles(VLPs) of...

Topics

Foot-and-Mouth Disease Virus
Animals
Foot-and-Mouth Disease
Serogroup
Guinea Pigs
Vaccines, Virus-Like Particle
Antibodies, Viral
Antigens, Viral
Capsid Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Vaccines

Mutation

Source

Identifiers

PMID: 39098702
DOI: 10.1016/j.ijbiomac.2024.134366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39098702-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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