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Article

IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies.

The Journal of experimental medicine - 5 May 2014

Duong Francois H T, Trincucci Gaia, Boldanova Tujana, Calabrese Diego, Campana Benedetta, Krol Ilona, Durand Sarah C, Heydmann Laura, Zeisel Mirjam B, Baumert Thomas F, Heim Markus H

Abstract excerpt

The molecular mechanisms that link IFN-λ3 genotypes to differential induction of interferon (IFN)-stimulated genes (ISGs) in the liver of patients with chronic hepatitis C (CHC) are not known. We measured the expression of IFN-λ and of the specific IFN-λ receptor chain (IFN-λR1) in 122 liver biopsies of patients with CHC and 53 control samples. The IFN-λ3 genotype was not associated with differential expression...

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Identifiers

PMID: 24752298
DOI: 10.1084/jem.20131557
PMCID: PMC4010915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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