Article
PEG-IFN alpha but not ribavirin alters NK cell phenotype and function in patients with chronic hepatitis C.
PloS one - 1 Jan 2014
Markova Antoaneta A, Mihm Ulrike, Schlaphoff Verena, Lunemann Sebastian, Filmann Natalie, Bremer Birgit, Berg Thomas, Sarrazin Christoph, Zeuzem Stefan, Manns Michael P, Cornberg Markus, Herrmann Eva, Wedemeyer Heiner
Abstract excerpt
BACKGROUND: Ribavirin (RBV) remains part of several interferon-free treatment strategies even though its mechanisms of action are still not fully understood. One hypothesis is that RBV increases responsiveness to type I interferons. Pegylated Interferon alpha (PEG-IFNa) has recently been shown to alter natural killer (NK) cell function possibly contributing to control of hepatitis C virus (HCV) infection....
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