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Article

Pegylated Interferon α-2a Triggers NK-Cell Functionality and Specific T-Cell Responses in Patients with Chronic HBV Infection without HBsAg Seroconversion.

PloS one - 1 Jan 2016

Bruder Costa Juliana, Dufeu-Duchesne Tania, Leroy Vincent, Bertucci Inga, Bouvier-Alias Magali, Pouget Noelle, Brevot-Lutton Ophelie, Bourliere Marc, Zoulim Fabien, Plumas Joel, Aspord Caroline

Abstract excerpt

Pegylated interferon α-2a (Peg-IFN-α) represents a therapeutic alternative to the prolonged use of nucleos(t)ide analog (NA) in chronic hepatitis B (CHB) infection. The mechanisms leading to a positive clinical outcome remain unclear. As immune responses are critical for virus control, we investigated the effects of Peg-IFN-α on both innate and adaptive immunity, and related it to the clinical evolution. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27348813
DOI: 10.1371/journal.pone.0158297
PMCID: PMC4922676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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