Article
Genome-wide association study supports the role of the immunological system and of the neurodevelopmental processes in response to haloperidol treatment.
Pharmacogenetics and genomics - 1 Jun 2014
Drago Antonio, Giegling Ina, Schäfer Martin, Hartmann Annette M, Konte Bettina, Friedl Marion, Serretti Alessandro, Rujescu Dan
Abstract excerpt
AIM: The aim of the study was to detect the genetic predictors of reseponse to haloperidol. BACKGROUND: Haloperidol is a benchmark drug for the pharmacological treatment of schizophrenia, but the genetics of its efficacy is yet to be elucidated. METHODS: A genome-wide association analysis was carried out in a small sample of patients treated with haloperidol (n=96) and the results were replicated in a larger...
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