Article
The importance of genetic susceptibility in Dupuytren's disease.
Clinical genetics - 1 May 2015
Becker K, Tinschert S, Lienert A, Bleuler P E, Staub F, Meinel A, Rößler J, Wach W, Hoffmann R, Kühnel F, Damert H-G, Nick H-E, Spicher R, Lenze W, Langer M, Nürnberg P, Hennies H C
Abstract excerpt
Dupuytren's disease (DD) is a progressive fibromatosis that causes the formation of nodules and cords in the palmar aponeurosis leading to flexion contracture of affected fingers. The etiopathogenesis is multifactorial with a strong genetic predisposition. It is the most frequent genetic disorder of connective tissues. We have collected clinical data from 736 unrelated individuals with DD who underwent surgical...
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