Article
Molecular signatures of proliferation and quiescence in hematopoietic stem cells.
PLoS biology - 1 Oct 2004
Venezia Teresa A, Merchant Akil A, Ramos Carlos A, Whitehouse Nathan L, Young Andrew S, Shaw Chad A, Goodell Margaret A
Abstract excerpt
Stem cells resident in adult tissues are principally quiescent, yet harbor enormous capacity for proliferation to achieve self renewal and to replenish their tissue constituents. Although a single hematopoietic stem cell (HSC) can generate sufficient primitive progeny to repopulate many recipients, little is known about the molecular mechanisms that maintain their potency or regulate their self renewal. Here we...
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